N-acetyl-5-methoxytryptamine,
Melatonin in produced by the Pinealocytes cells inside the pineal gland
Description
Melatonin is a hormone that is produced by the pineal gland that is about the size of a pea and is located in the center of the brain. Melatonin is used to regulate the sleeping cycle.

The pineal gland functions as a biological clock by secreting melatonin at night. The above chart shows the peak of melatonin at around 2 to 3 in the morning. Younger healthy people tend to peak at 2 a.m, while the elderly it is at 3 a.m.
Women going through menopause can also experience hormonal fluctuation that can cause a disturbance in their sleeping cycle that is linked to melatonin.
Melatonin Decreases with Age

Jet-Lag and Bad Sleeping Habits
Jet-lag is a condition caused by disruption of the biological clock. It changes your sleep-wake cycle when crossing several time zones during travel, and also when working rotating, night work or staying up late. Even just leaving the light on at night can decrease melatonin levels causing a disruption in your sleep cycle.
Symptoms of Decreased Melatonin
The following symptoms maybe be the result of decreased melatonin:
- Fatigue
- Early Awakening
- Insomnia
- Headaches
- Fuzzy thinking
- Irritability
- Constipation
- Reduced Immunity
Melatonin and Your Health
Melatonin has been credited in improving health and preventing disease. The following diseases are list below:
- Alzheimer's Disease
- Osteoporosis
- Arthritis
- Cancer
- Heart Disease
- Suppressed Immune System
- Stress and Anxiety related Diseases
- Rapid Aging
Depression and Seasonal Affective Disorder are known to diminish nighttime release of melatonin and abnormal sensitivity to melatonin suppression by light, principally the blue light is the one that is the suppressor of melatonin. Studies have shown that melatonin has positive results for treating depression and SAD.
Can we reset our body clocks with Melatonin?
Most people's body clock will reset by taking melatonin. It is best taken in the evening after sunset or around 30-45 minutes before bedtime.
Will Melatonin help you sleep better?
Yes. Many have reported that it helped put them to sleep and that their sleep was more soundly. Melatonin use is most likely to be more effective with the older population then the younger. By the time your 60 years old your pineal gland is producing only a fraction of melatonin compared to a 20 year old.
Natural alternatives to taking Melatonin
A better way to increase your natural melatonin levels is by eating tryptophan rich foods like turkey, milk, bananas and eggs. When eaten tryptophan forms serotonin which converts to melatonin. Another way to stimulate melatonin is to get enough sunlight in the daytime, especially in the morning.
Does Melatonin Improve Mental Performance?
Yes. Studies have confirmed that when melatonin is taken at bedtime the night before, the following morning there has been evidence of improved mental performance.
Obesity
Research has confirmed that melatonin is involved in the regulation of body weight. When combined with calcium, melatonin may be helpful in treating weight problems like obesity.
Life Extension
Melatonin has been shown to improve immune system function and extend lifespan. Melatonin was administered each evening before sleep. The treated subjects become more healthy. They had better posture, increased activity levels and thicker and lustrous hair.
Melatonin secretion drops off naturally with age. This age related reduction may account why many older people have difficulty sleeping at night, and why are are so fatigued during the daytime.
Administration of melatonin was found to increase lifespan by about 20%.
Antioxidant Properties
Besides it's primary function as a biological clock regulator, melatonin also exerts powerful antioxidant properties. Melatonin is an antioxidant that has demonstrated to prevent damage to DNA by some carcinogens that cause cancer. It also has been effective in protecting against brain injury or damage caused by oxidative stress such as UV or heat exposure. Oxidative damage in the brain is caused by free radicals, a natural byproduct of normal metabolism of oxygen during times of excessive environmental stress.
Anti Stress
Administration of melatonin can also counteract the immune suppressing effects of acute anxiety. Thymus weight, antibody production, and the ability to fight of lethal infection was measured and confirmed in studies.
Immune System
Studies have shown that melatonin might be useful in fighting infectious disease including viruses like HIV and bacterial infections.
Alzheimer's Disease
Studies have found there are reduced levels of melatonin in the cerebrospinal fluid in people who have Alzheimer's disease compared to healthy subjects. It is possible that restoration of melatonin levels in Alzheimer's patients may be effective in treating the disease.
Cancer Treatment
Studies have shown that melatonin appears to inhibit growth of different types of tumors. Based on its effects on the immune system, melatonin could be used in association with other anti-cancer treatments.
ADHD
Studies have shown that after administration of melatonin to Attention-deficit / hyperactivity disorder patients, the time needed to fall asleep is significantly reduced.
Fertility
Studies have found that melatonin administration in the evening in premenopausal woman has restored fertility, menstruation and prevented depression associated with menopause. It is also believed that melatonin has an effect on sexual development.
Headaches
Research has shown that melatonin is an effective preventive for cluster headaches and migraines.
Gallbladder Stones
Studies have shown that presence of melatonin in the gallbladder has many protective properties like converting cholesterol into bile, increasing the mobility of gallstones from the gallbladder, preventing oxidative stress and even decreases the amount of cholesterol produced in the gallbladder by regulating cholesterol that passes through the intestinal wall.
Sunlight and Electromagnetism
Sunlight is the primary influence that regulates the internal clock and the associated melatonin hormone levels in the body. There is evidence that the earth's magnetic field may also be an environmental signal affecting circadian rhythm in the body.
Exposure to electromagnetic fields from appliances and high-voltage power lines may be even more significant in suppressing melatonin levels then though before.
Dosage
Dosage can very from person to person ranging from 0.1 to 200 mg depending on the level of natural melatonin in the body. Age will play a big role on how much dosage will be used. Patients will usually start from 1 mg and increase until desired effect has been reached. Average dosage is between 3 and 10 mg.